On non-UK domain names it is good practice to have the 'Registrar Lock' enabled on your domains. This prevents your domain name being transferred or edited by anyone. However, to change the domain name servers you will need to temporarily disable the 'Registrar Lock' as follows:
1) Login to your Client Portal
2) Go to Domains > Select Domain > View Details on required domain
3) Now go to 'Registrar Lock' tab
4) Select 'Disable Registrar Lock'
5) Now go to 'Nameservers' tab
6) Enter new name servers and click 'Change Nameserverts'
7) Now go back to 'Registrar Lock' tab
8) Select 'Enable Registrar Lock' to protect your domain name.
Your name server changes are immediately submitted however do allow up to 48 hours for the global DNS to catch up with your changes.